Journal: Biomedical Microdevices

Article Title: A review of microsampling techniques and their social impact

doi: 10.1007/s10544-019-0412-y

Figure Lengend Snippet: Microneedle-based microbiopsies were used in skin and blood microsampling. a ) A side-by-side comparison between conventional punch biopsy and the skin microbiopsy. b ) The spring-loaded applicator used in microbiopsy application. c ) After application, the microneedle captured pieces of skin tissue in the channel. d ) Spatial detection of HPV by sampling cutaneous warts. Skin microbiopsy provided a more accurate spatial detection as demonstrated by DNA gel electrophoresis. e ) Designs of skin (top) and absorbent microbiopsies (bottom). The main difference between the two designs was the middle absorbent layer. f ) The absorbent microbiopsy was used to sample patients with Leishmaniasis in rural areas. g ) The PCR data suggested the absorbent microbiopsy was able to detect Leishmaniasis more accurately than the finger-prick method. Pictures retrieved from Lin et al. , Tom et al. and Kirstein et al. . All figures are under a Creative Commons Attribution 2.0. Full terms at http://creativecommons.org/licenses/by/2.0

Article Snippet: In 2017, Kirstein et al. reported an absorbent microneedle-based device called an absorbent microbiopsy; a modified version of skin microbiopsy, for sampling of skin and blood mixture (Kirstein et al. ).

Techniques: Comparison, Sampling, DNA Gel Electrophoresis